[Anti-cancer effects of BRMs associated with nutrition in cancer patients]

Gan To Kagaku Ryoho. 1988 Apr;15(4 Pt 2-3):1615-20.
[Article in Japanese]


Nutritional deficiencies are believed to be instrumental in producing reduced immune responses in a variety of animal species. Malnutrition may result in an increase or a decrease in immune functions, depending upon its degree, and also the timing and severity of the nutritional protein deprivation. Our experimental data suggest that there is a significant impairment of cytotoxic activity against K-562 and of the ability of spleen cells to produce interferon in protein-deprived mice in comparison with control mice. Paradoxically accelerated tumor growth after administration of OK-432 or Lentinan was also noted in protein-deficient tumor-bearing mice. In addition, a clinical randomized study of advanced or recurrent gastric cancer patients treated with MMC and FT(MF) with or without lentinan was performed. We recognized excellent end-point results only in the lentinan-treated patients with normal protein levels, while no effect of this agent was seen in patients with low serum protein levels (below 5.9/dl). Aggressive postoperative chemotherapy for cases with distant lymph node metastasis was performed under active nutritional support without any depression of metabolic and immunological states, resulting in a good 5-year survival rate (36.9%).

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / therapeutic use*
  • Animals
  • Esophageal Neoplasms / therapy
  • Humans
  • Lentinan / pharmacology
  • Mice
  • Mice, Inbred C3H
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Nutrition Disorders / immunology*
  • Picibanil / pharmacology
  • Stomach Neoplasms / therapy


  • Adjuvants, Immunologic
  • Lentinan
  • Picibanil