The antimicrobial effect behind Cannabis sativa

Pharmacol Res Perspect. 2021 Apr;9(2):e00761. doi: 10.1002/prp2.761.

Abstract

The development of multidrug-resistant bacteria has revealed the need for new antimicrobial compounds. Cannabis sativa preparations have a long history of medical applications, including the treatment of infectious diseases. This review collects the information about the activity of C. sativa extracts and its main components (cannabinoids and terpenes) against pathogenic bacteria and fungus, to assess its potential using as antimicrobial agents.

Keywords: Cannabis sativa; antimicrobial activity; cannabinoids; terpenes.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology*
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Infections / drug therapy*
  • Cannabinoids / pharmacology
  • Cannabinoids / therapeutic use
  • Cannabis / chemistry*
  • Cell Membrane / metabolism
  • Cell Membrane Permeability / drug effects
  • Disease Models, Animal
  • Drug Resistance, Multiple, Bacterial
  • Drug Synergism
  • Humans
  • Microbial Sensitivity Tests
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Terpenes / pharmacology
  • Terpenes / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Cannabinoids
  • Plant Extracts
  • Terpenes