Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin)

Wei Ying; Kechun Tang; Ennio Avolio; Jan M Schilling; Teresa Pasqua; Matthew A Liu; Hongqiang Cheng; Hong Gao; Jing Zhang; Sumana Mahata; Myung S Ko; Gautam Bandyopadhyay; Soumita Das; David M Roth; Debashis Sahoo; Nicholas J G Webster; Farah Sheikh; Gourisankar Ghosh; Hemal H Patel; Pradipta Ghosh; Geert van den Bogaart; Sushil K Mahata

doi:10.1161/HYPERTENSIONAHA.120.16809

Immunosuppression of Macrophages Underlies the Cardioprotective Effects of CST (Catestatin)

Hypertension. 2021 May 5;77(5):1670-1682. doi: 10.1161/HYPERTENSIONAHA.120.16809. Epub 2021 Apr 7.

Authors

Wei Ying^#¹, Kechun Tang^#², Ennio Avolio^{1

3}, Jan M Schilling^{2

4}, Teresa Pasqua^{2

5}, Matthew A Liu¹, Hongqiang Cheng⁶, Hong Gao¹, Jing Zhang¹, Sumana Mahata¹, Myung S Ko⁷, Gautam Bandyopadhyay¹, Soumita Das⁸, David M Roth^{2

4}, Debashis Sahoo^{9

10}, Nicholas J G Webster^{2

1}, Farah Sheikh¹, Gourisankar Ghosh⁷, Hemal H Patel^{2

4}, Pradipta Ghosh^{1

11}, Geert van den Bogaart^{12

13}, Sushil K Mahata^{2

1}

Affiliations

¹ Department of Medicine (W.Y., E.A., M.A.L., H.G., J.Z., S.M., G.B., F.S., N.J.G.W., P.G., S.K.M.), University of California San Diego, La Jolla.
² VA San Diego Healthcare System, CA (T.P., K.T., J.M.S., D.M.R., N.J.G.W., H.H.P., S.K.M.).
³ Comparative Anatomy & Cytology, Dept. of Biology, Ecology and Earth Science, University of Calabria, Arcavacata di Rende-Cosenza, Italy (E.A.).
⁴ Department of Anesthesiology (J.M.S., D.M.R., H.H.P.), University of California San Diego, La Jolla.
⁵ Department of Health Science, University Magna Graecia of Catanzaro, 88100 Catanzaro, Italy (T.P.).
⁶ Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, China (H.C.).
⁷ Department of Chemistry and Biochemistry (M.S.K., G.G.), University of California San Diego, La Jolla.
⁸ Department of Pathology (S.D.), University of California San Diego, La Jolla.
⁹ Department of Pediatrics (D.S.), University of California San Diego, La Jolla.
¹⁰ Department of Computer Science and Engineering (D.S.), University of California San Diego, La Jolla.
¹¹ Cellular and Molecular Medicine (P.G.), University of California San Diego, La Jolla.
¹² Department of Molecular Immunology and Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, the Netherlands (G.v.d.B.).
¹³ Department of Tumor Immunology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, the Netherlands (G.v.d.B.).

^# Contributed equally.

Abstract

[Figure: see text].

Keywords: bone marrow; chromogranin A; hypertension; inflammation; macrophages.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Cardiotonic Agents / pharmacology*
Cardiotonic Agents / therapeutic use
Chromogranin A / genetics*
Chromogranin A / metabolism
Chromogranin A / pharmacology
Chromogranin A / therapeutic use
Hypertension / drug therapy*
Hypertension / metabolism
Hypertension / pathology
Hypertrophy, Left Ventricular / genetics*
Hypertrophy, Left Ventricular / metabolism
Hypertrophy, Left Ventricular / pathology
Immunosuppression Therapy
Macrophages / drug effects*
Macrophages / metabolism
Macrophages / pathology
Male
Mice
Mice, Knockout
Peptide Fragments / pharmacology*
Peptide Fragments / therapeutic use

Substances

Cardiotonic Agents
Chromogranin A
Peptide Fragments
chromogranin A (344-364)

Abstract

Publication types

MeSH terms

Substances

Grants and funding