Salvia sharifii Rech. & Esfand is a folkloric endemic medicinal plant which is found in south of Iran. Phytochemical screening and antimicrobial activities from the aerial parts of S. sharifii were investigated. The essential oil was extracted by hydro-distillation using Clevenger type apparatus and analyzed using GC-MS. The main constituents were, linalool (20.74%), spathulenol (7.98%), caryophyllene oxide (4.77%), isopentyl isovalerate (4.48%), hexyl isovalerate (4.22%), α -gurjunene (4.16%), α -cadinol (3.77%), γ-terpinene (3.52%), terpinen-4-ol (3.37%) and sabinene (3.13). Total phenolic content was 31.39 mg gallic acid equivalents/g dry weight, and IC50 values in the radical scavenging assay was 1423 mg/mL. The in vitro antimicrobial activity of the essential oil of S. sharifii were studied by disc diffusion method. The results showed that the oil exhibited good antimicrobial activity against all medically important pathogens compare to standard antibiotics.
Keywords: Antimicrobial activity; Antioxidant; Salvia sharifii; essential oil; total phenolic content.