Clinical evaluation of the treatment of multiple gingival recessions with connective tissue graft or concentrated growth factor using tunnel technique: a randomized controlled clinical trial

Clin Oral Investig. 2021 Nov;25(11):6347-6356. doi: 10.1007/s00784-021-03935-3. Epub 2021 Apr 8.


Objective: To assess the effectiveness of the combination of tunnel technique (TT) and concentrated growth factor (CGF) for root coverage in treating multiple gingival recessions (GR) and compare with the connective tissue graft (CTG).

Materials and methods: Forty patients with Miller Class I and II maxillary or mandibular GR were randomly divided into two groups as follows: TT + CTG and TT + CGF. The results at baseline and 6 months were evaluated for the following clinical parameters: complete root coverage (CRC), mean root coverage (MRC), gingival thickness (GT), gingival recession width (RW), gingival recession depth (RD), and keratinized tissue width (KTW).

Results: At 6 months, a statistically significant difference was found in RD, RW, MRC, CRC, KTW, and GT compared with the baseline (p < 0.05). MRC was determined 89.52±16.36% in the TT + CTG and 76.60±24.10% in the TT + CGF (p < 0.05). CRC was achieved in 66.7% of the TT + CTG and 47.4% of the TT + CGF (p < 0.05). The increase in KTW and GT was significantly better in the TT + CTG group compared to the TT + CGF (p < 0.05).

Conclusions: The study showed that TT + CGF did not improve the results as much as TT + CTG in the treatment of Miller Class I and II GR. However, this finding is not sufficient to advocate the true clinical effects of CGF on GR treatment with TT.

Clinical relevance: CGF could not serve as a direct alternative biomaterial to the gold standard CTG.

Trial registration: Identification Number: NCT04561947.

Keywords: Connective tissue graft; Gingival recession; Growth factors; Plastic periodontal surgery.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Connective Tissue
  • Gingiva
  • Gingival Recession* / surgery
  • Humans
  • Intercellular Signaling Peptides and Proteins
  • Tooth Root
  • Treatment Outcome


  • Intercellular Signaling Peptides and Proteins

Associated data