Vancomycin Infusion Reaction - Moving beyond "Red Man Syndrome"

doi:10.1056/NEJMp2031891

. 2021 Apr 8;384(14):1283-1286.

doi: 10.1056/NEJMp2031891. Epub 2021 Apr 3.

Vancomycin Infusion Reaction - Moving beyond "Red Man Syndrome"

Santiago Alvarez-Arango¹, S Michelle Ogunwole¹, Thomas D Sequist¹, Caitlin M Burk¹, Kimberly G Blumenthal¹

Affiliations

Affiliation

¹ From the Divisions of Allergy and Clinical Immunology and of Clinical Pharmacology (S.A.A.) and the Department of Medicine (S.M.O.), Johns Hopkins University, and the Johns Hopkins Center for Health Equity (S.M.O.) - both in Baltimore; and the Department of Medicine, Brigham and Women's Hospital (T.D.S.), Harvard Medical School (T.D.S., K.G.B.), and the Division of Rheumatology, Allergy, and Immunology (C.M.B., K.G.B.), and the Edward P. Lawrence Center for Quality and Safety (K.G.B.), Massachusetts General Hospital - all in Boston.

PMID: 33830710
PMCID: PMC9235042
DOI: 10.1056/NEJMp2031891

Vancomycin Infusion Reaction - Moving beyond "Red Man Syndrome"

Santiago Alvarez-Arango et al. N Engl J Med. 2021.

. 2021 Apr 8;384(14):1283-1286.

doi: 10.1056/NEJMp2031891. Epub 2021 Apr 3.

Authors

Santiago Alvarez-Arango¹, S Michelle Ogunwole¹, Thomas D Sequist¹, Caitlin M Burk¹, Kimberly G Blumenthal¹

Affiliation

¹ From the Divisions of Allergy and Clinical Immunology and of Clinical Pharmacology (S.A.A.) and the Department of Medicine (S.M.O.), Johns Hopkins University, and the Johns Hopkins Center for Health Equity (S.M.O.) - both in Baltimore; and the Department of Medicine, Brigham and Women's Hospital (T.D.S.), Harvard Medical School (T.D.S., K.G.B.), and the Division of Rheumatology, Allergy, and Immunology (C.M.B., K.G.B.), and the Edward P. Lawrence Center for Quality and Safety (K.G.B.), Massachusetts General Hospital - all in Boston.

PMID: 33830710
PMCID: PMC9235042
DOI: 10.1056/NEJMp2031891

No abstract available

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Figures

None — **Dermatologic Findings in Patients Varying in Age, Sex, and Skin Color.**
The immediate reaction to drugs, including the vancomycin infusion reaction, can present as erythema that can be confluent or blotchy, typically involving the head and neck but also the trunk, extremities, and palms or soles (Panels A through D) or urticaria that can be localized or diffuse (Panels E through H).

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Comment in

Moving beyond "Red Man Syndrome".
Korman TM. Korman TM. N Engl J Med. 2021 Jul 8;385(2):192. doi: 10.1056/NEJMc2107779. N Engl J Med. 2021. PMID: 34233103 No abstract available.

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References

1. Austin JP, Foster BA, Empey A. Replace red man syndrome with vancomycin flushing reaction. Hosp Pediatr 2020; 10:623–4. - PubMed
1. Brave Heart MY, DeBruyn LM. The American Indian Holocaust: healing historical unresolved grief. Am Indian Alsk Native Ment Health Res 1998; 8:56–78. - PubMed
1. Cerdeña JP, Plaisime MV, Tsai J. From race-based to race-conscious medicine: how anti-racist uprisings call us to act. Lancet 2020; 396:1125–8. - PMC - PubMed
1. Alvarez-Arango S, Yerneni S, Tang O, et al. Vancomycin hypersensitivity reactions documented in electronic health records. J Allergy Clin Immunol Pract 2020. October 1 (Epub ahead of print). - PMC - PubMed
1. Myers AL, Gaedigk A, Dai H, James LP, Jones BL, Neville KA. Defining risk factors for red man syndrome in children and adults. Pediatr Infect Dis J 2012; 31:464–8. - PMC - PubMed

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[1] Austin JP, Foster BA, Empey A. Replace red man syndrome with vancomycin flushing reaction. Hosp Pediatr 2020; 10:623–4. - PubMed

[2] Austin JP, Foster BA, Empey A. Replace red man syndrome with vancomycin flushing reaction. Hosp Pediatr 2020; 10:623–4. - PubMed

[3] Brave Heart MY, DeBruyn LM. The American Indian Holocaust: healing historical unresolved grief. Am Indian Alsk Native Ment Health Res 1998; 8:56–78. - PubMed

[4] Brave Heart MY, DeBruyn LM. The American Indian Holocaust: healing historical unresolved grief. Am Indian Alsk Native Ment Health Res 1998; 8:56–78. - PubMed

[5] Cerdeña JP, Plaisime MV, Tsai J. From race-based to race-conscious medicine: how anti-racist uprisings call us to act. Lancet 2020; 396:1125–8. - PMC - PubMed

[6] Cerdeña JP, Plaisime MV, Tsai J. From race-based to race-conscious medicine: how anti-racist uprisings call us to act. Lancet 2020; 396:1125–8. - PMC - PubMed

[7] Alvarez-Arango S, Yerneni S, Tang O, et al. Vancomycin hypersensitivity reactions documented in electronic health records. J Allergy Clin Immunol Pract 2020. October 1 (Epub ahead of print). - PMC - PubMed

[8] Alvarez-Arango S, Yerneni S, Tang O, et al. Vancomycin hypersensitivity reactions documented in electronic health records. J Allergy Clin Immunol Pract 2020. October 1 (Epub ahead of print). - PMC - PubMed

[9] Myers AL, Gaedigk A, Dai H, James LP, Jones BL, Neville KA. Defining risk factors for red man syndrome in children and adults. Pediatr Infect Dis J 2012; 31:464–8. - PMC - PubMed

[10] Myers AL, Gaedigk A, Dai H, James LP, Jones BL, Neville KA. Defining risk factors for red man syndrome in children and adults. Pediatr Infect Dis J 2012; 31:464–8. - PMC - PubMed

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Vancomycin Infusion Reaction - Moving beyond "Red Man Syndrome"

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