Tackling neurodegenerative diseases with genomic engineering: A new stem cell initiative from the NIH

Neuron. 2021 Apr 7;109(7):1080-1083. doi: 10.1016/j.neuron.2021.03.022.


The iPSC Neurodegenerative Disease Initiative (iNDI) is the largest-ever iPSC genome engineering project. iNDI will model more than 100 mutations associated with Alzheimer's disease and related dementias (ADRD) in isogenic iPSC lines. Resulting cell lines and phenotypic datasets will be broadly shared.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Alzheimer Disease / therapy
  • Genetic Engineering / methods*
  • Humans
  • Induced Pluripotent Stem Cells / transplantation
  • Neural Stem Cells / transplantation
  • Neurodegenerative Diseases / genetics*
  • Neurodegenerative Diseases / therapy*
  • Stem Cell Research*
  • Stem Cell Transplantation*