HLA-DPB1 alleles in hepatitis B vaccine response: A meta-analysis

Medicine (Baltimore). 2021 Apr 9;100(14):e24904. doi: 10.1097/MD.0000000000024904.


Background: The role of the HLA-DRB1 and HLA-DQB1 genes in the antibody response to hepatitis B (HB) vaccine has been well established; however, the involvement of the HLA-DPB1 allele in the HB vaccine immune response remained to be clarified by a systematic review.

Methods: A meta-analysis was performed in which databases were searched for relevant studies published in English or Chinese up until June 1, 2020. Six studies were identified and a total of 10 alleles were processed into statistical processing in this meta-analysis.

Results: Three thousand one hundred forty four subjects (including 2477 responders and 667 non-responders) were included in this research. Alleles HLA-DPB1∗02:02, DPB1∗03:01, DPB1∗04:01, DPB1∗04:02, and DPB1∗14:01 were found to be associated with a significant increase in the antibody response to HB vaccine, and their pooled odds ratios (ORs) were 4.53, 1.57, 3.33, 4.20, and 1.79, respectively; whereas DPB1∗05:01 (OR = 0.73) showed the opposite correlation.

Conclusions: These findings suggested that specific HLA-DPB1 alleles are associated with the antibody response to HB vaccine.

Publication types

  • Meta-Analysis

MeSH terms

  • HLA-DRB1 Chains / genetics
  • HLA-DRB1 Chains / immunology*
  • Hepatitis B Antibodies / immunology
  • Hepatitis B Vaccines / immunology*
  • Humans
  • Vaccination Coverage / statistics & numerical data


  • HLA-DRB1 Chains
  • Hepatitis B Antibodies
  • Hepatitis B Vaccines