Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective

doi:10.1016/j.tem.2021.03.002

Review

. 2021 Jun;32(6):351-366.

doi: 10.1016/j.tem.2021.03.002. Epub 2021 Apr 5.

Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective

Lili Huang¹, Lin Gao¹, Chen Chen²

Affiliations

¹ School of Biomedical Science and Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Australia.
² School of Biomedical Science and Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Australia. Electronic address: chen.chen@uq.edu.au.

PMID: 33832826
DOI: 10.1016/j.tem.2021.03.002

Review

Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective

Lili Huang et al. Trends Endocrinol Metab. 2021 Jun.

. 2021 Jun;32(6):351-366.

doi: 10.1016/j.tem.2021.03.002. Epub 2021 Apr 5.

Authors

Lili Huang¹, Lin Gao¹, Chen Chen²

Affiliations

¹ School of Biomedical Science and Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Australia.
² School of Biomedical Science and Institute for Molecular Bioscience, University of Queensland, St Lucia, Brisbane, Australia. Electronic address: chen.chen@uq.edu.au.

PMID: 33832826
DOI: 10.1016/j.tem.2021.03.002

Abstract

Medium-chain fatty acids (MCFAs) serve not only as an energy source but also regulate glucose and lipid metabolism. The unique transport and rapid metabolism of MCFAs provide additional clinical benefits over other substrates such as long-chain fatty acids (LCFAs) and have prompted interest in the use of MCFAs for treating metabolic and neurological disorders. This review focuses on the metabolic role of MCFAs in modulating cellular signaling and regulating key circulating metabolites and hormones. The potential of MCFAs in treating various metabolic diseases in a clinical setting has also been analyzed.

Keywords: glucose metabolism; lipid metabolism; medium-chain fatty acids; metabolic/neurological diseases.

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Conflict of interest statement

Declaration of Interests The authors declare no conflicts of interest.

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Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective

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Role of Medium-Chain Fatty Acids in Healthy Metabolism: A Clinical Perspective

Authors

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Conflict of interest statement

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