Outer Membrane Vesicles (OMVs) Produced by Gram-Negative Bacteria: Structure, Functions, Biogenesis, and Vaccine Application

Noemi Furuyama; Marcelo Palma Sircili

doi:10.1155/2021/1490732

Outer Membrane Vesicles (OMVs) Produced by Gram-Negative Bacteria: Structure, Functions, Biogenesis, and Vaccine Application

Biomed Res Int. 2021 Mar 24:2021:1490732. doi: 10.1155/2021/1490732. eCollection 2021.

Authors

Noemi Furuyama¹, Marcelo Palma Sircili¹

Affiliation

¹ Laboratory of Genetics, Butantan Institute, São Paulo, Brazil.

Abstract

Gram-negative bacteria produce outer membrane vesicles (OMVs) with 10 to 300 nm of diameter. The contribution of OMVs to bacterial pathogenesis is a topic of great interest, and their capacity to be combined with antigens impact in the future to the development of vaccines.

Publication types

Review

MeSH terms

Bacterial Vaccines / immunology*
Cell Membrane / chemistry*
Cell Membrane / immunology*
Drug Resistance, Microbial
Gram-Negative Bacteria / immunology*
Models, Biological

Substances

Bacterial Vaccines