Recurrent anti-NMDAR encephalitis during pregnancy combined with two antibodies positive

Arch Womens Ment Health. 2021 Dec;24(6):1045-1050. doi: 10.1007/s00737-021-01124-5. Epub 2021 Apr 9.


Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is an autoimmune synaptic encephalitis likely mediated by neuronal surface antibody. Clinically, it is characterized by a variety of neurological and psychiatric symptoms, predominantly affecting young women. Recurrent anti-NMDAR cases combined with double-antibody positive during pregnancy have not been reported. We report a 19-year-old pregnant woman with recurrent anti-NMDAR encephalitis and double-antibody positive. Through our case report and a review of the literature, we hope to heighten an awareness of anti-NMDAR encephalitis, particularly in a pregnant setting.

Keywords: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis; Double-antibody positive; Pregnancy; Recurrent.

Publication types

  • Research Support, Non-U.S. Gov't