Printing Methods in the Production of Orodispersible Films

AAPS PharmSciTech. 2021 Apr 9;22(3):129. doi: 10.1208/s12249-021-01990-3.


Orodispersible film (ODF) formulations are promising and progressive drug delivery systems that are widely accepted by subjects across all the age groups. They are traditionally fabricated using the most popular yet conventional method called solvent casting method. The most modern and evolving method is based on printing technologies and such printed products are generally termed as printed orodispersible films (POFs). This modern technology is well suited to fabricate ODFs across different settings (laboratory or industrial) in general and in a pharmacy setting in particular. The present review provides an overview of various printing methods employed in fabricating POFs. Particularly, it provides insight about preparing POFs using inkjet, flexographic, and three-dimensional printing (3DP) or additive manufacturing techniques like filament deposition modeling, hot-melt ram extrusion 3DP, and semisolid extrusion 3DP methods. Additionally, the review is focused on patenting trends in POFs using ESPACENET, a European Patent Office search database. Finally, the review captures future market potential of 3DP in general and ODFs market potential in particular.

Keywords: 3D printing; ODFs; POFs; film; flexographic printing; inkjet printing; pharmacy; printing.

Publication types

  • Review

MeSH terms

  • Administration, Oral
  • Drug Compounding / methods*
  • Drug Delivery Systems*
  • Humans
  • Patents as Topic
  • Printing, Three-Dimensional*