Gastrointestinal Tract Lymphomas

Arch Pathol Lab Med. 2021 Dec 1;145(12):1585-1596. doi: 10.5858/arpa.2020-0661-RA.


Context.—: The gastrointestinal (GI) tract is the most common site of extranodal non-Hodgkin lymphoma, accounting for 20% to 40% of all extranodal lymphomas. The majority of these are systemic processes secondarily involving the GI tract. Primary GI lymphomas are less common, accounting for approximately 10% to 15% of all non-Hodgkin lymphomas. Most non-Hodgkin lymphomas involving the GI tract are of B-cell lineage, of which diffuse large B-cell lymphoma is the most common subtype, irrespective of location.

Objective.—: To review the lymphoproliferative neoplasms of B-cell and T-cell lineage involving the luminal GI tract according to the most prevalent subtypes at each anatomic site.

Data source.—: Systematic search of the PubMed database for updated literature on GI lymphoma epidemiology, subtypes, clinical, endoscopic, and genetic findings. Histologic images are derived from our collection of clinical cases.

Conclusions.—: The GI tract is the most common site of extranodal lymphoproliferative neoplasms. Recognition of the most frequently encountered GI lymphomas is imperative for patient management and treatment.

Publication types

  • Review

MeSH terms

  • B-Lymphocytes
  • Gastrointestinal Neoplasms* / diagnosis
  • Gastrointestinal Neoplasms* / epidemiology
  • Humans
  • Lymphoma, Large B-Cell, Diffuse*
  • Lymphoma, Non-Hodgkin*