doi: 10.1016/j.tim.2021.03.007.
Epub 2021 Apr 6.
Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens
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- PMID: 33836929
- DOI: 10.1016/j.tim.2021.03.007
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Evolutionary constraints on the acquisition of antimicrobial peptide resistance in bacterial pathogens
Trends Microbiol.
2021 Dec.
Abstract
Antimicrobial peptides (AMPs) offer a potential solution to the antibiotic resistance crisis. Recent studies have revealed important evolutionary constraints on the evolution and horizontal spread of AMP resistance in bacteria. Here, we summarize these advances and highlight their importance for therapeutic development of AMPs.
Keywords: antibiotic resistance; antimicrobial peptide resistance; bacterial evolution.
Copyright © 2021 Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of interests There are no interests to declare.
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