Yttrium-90 Radioembolization to the Prostate Gland: Proof of Concept in a Canine Model and Clinical Translation

Samdeep K Mouli; Simone Raiter; Kathleen Harris; Amrutha Mylarapu; Malcolm Burks; Weiguo Li; Andrew C Gordon; Ali Khan; Monica Matsumoto; Keith L Bailey; Alexander S Pasciak; Sasicha Manupipatpong; Clifford R Weiss; David Casalino; Frank H Miller; Vanessa L Gates; Elias Hohlastos; Robert J Lewandowski; Dong-Hyun Kim; Matthew R Dreher; Riad Salem

doi:10.1016/j.jvir.2021.01.282

Yttrium-90 Radioembolization to the Prostate Gland: Proof of Concept in a Canine Model and Clinical Translation

J Vasc Interv Radiol. 2021 Aug;32(8):1103-1112.e12. doi: 10.1016/j.jvir.2021.01.282. Epub 2021 Apr 9.

Authors

Samdeep K Mouli¹, Simone Raiter², Kathleen Harris², Amrutha Mylarapu², Malcolm Burks², Weiguo Li², Andrew C Gordon², Ali Khan², Monica Matsumoto², Keith L Bailey³, Alexander S Pasciak⁴, Sasicha Manupipatpong⁴, Clifford R Weiss⁴, David Casalino⁵, Frank H Miller⁵, Vanessa L Gates², Elias Hohlastos², Robert J Lewandowski², Dong-Hyun Kim⁵, Matthew R Dreher⁶, Riad Salem²

Affiliations

¹ Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL. Electronic address: s-mouli@northwestern.edu.
² Department of Radiology, Section of Interventional Radiology, Northwestern University, Chicago, IL.
³ Veterinary Diagnostic Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL.
⁴ Department of Radiology and Radiological Science, Division of Vascular and Interventional Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD.
⁵ Department of Radiology, Section of Body Imaging, Northwestern University, Chicago, IL.
⁶ Boston Scientific Corporation, Marlborough, MA.

PMID: 33839262
DOI: 10.1016/j.jvir.2021.01.282

Abstract

Purpose: To investigate the feasibility, safety, and absorbed-dose distribution of prostatic artery radioembolization (RE) in a canine model.

Materials and methods: Fourteen male castrated beagles received dihydroandrosterone/estradiol to induce prostatic hyperplasia for the duration of the study. Each dog underwent fluoroscopic prostatic artery catheterization. Yttrium-90 (⁹⁰Y) microspheres (TheraSphere; Boston Scientific, Marlborough, Massachusetts) were delivered to 1 prostatic hemigland (dose escalation from 60 to 200 Gy), with the contralateral side serving as a control. Assessments for adverse events were performed throughout the follow-up (Common Terminology Criteria for Adverse Events v5.0). Positron emission tomography/magnetic resonance (MR) imaging provided a confirmation after the delivery of absorbed-dose distribution. MR imaging was performed before and 3, 20, and 40 days after RE. Tissue harvest of the prostate, rectum, bladder, urethra, penis, and neurovascular bundles was performed 60 days after RE.

Results: All the animals successfully underwent RE. Positron emission tomography/MR imaging demonstrated localization to and good coverage of only the treated hemigland. No adverse events occurred. The MR imaging showed a significant dose-dependent decrease in the treated hemigland size at 40 days (25%-60%, P < .001). No extraprostatic radiographic changes were observed. Necropsy demonstrated no gross rectal, urethral, penile, or bladder changes. Histology revealed RE-induced changes in the treated prostatic tissues of the highest dose group, with gland atrophy and focal necrosis. No extraprostatic RE-related histologic findings were observed.

Conclusions: Prostate ⁹⁰Y RE is safe and feasible in a canine model and leads to focal dose-dependent changes in the gland without inducing unwanted extraprostatic effects. These results suggest that an investigation of nonoperative prostate cancer is warranted.

MeSH terms

Animals
Brachytherapy*
Dogs
Embolization, Therapeutic*
Humans
Male
Prostate
Prostatic Neoplasms* / diagnostic imaging
Prostatic Neoplasms* / radiotherapy
Yttrium Radioisotopes

Substances

Yttrium Radioisotopes
Yttrium-90