Relationships between polyamine, deoxyribonucleic acid and oestrogen receptor binding site concentrations in human breast tumours

Eur J Cancer Clin Oncol. 1988 Apr;24(4):603-13. doi: 10.1016/0277-5379(88)90288-x.

Abstract

Concentrations of polyamines, DNA and oestrogen receptor (ER) binding sites have been estimated in 23 malignant and 2 benign breast tumours. Polyamine and DNA concentrations, expressed per unit wet weight of tissue, were significantly higher in ER-poor (less than 10 fmol/mg cytosol protein) than in ER-rich tumours. Spermidine/spermine ratios were similar in ER-poor and ER-rich tumours. There was a relationship between polyamine and DNA levels and when polyamine concentrations were expressed per unit weight of DNA those in ER-poor tumours did not differ from those in ER-rich tumours. Possible reasons for these findings are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / analysis*
  • DNA, Neoplasm / analysis*
  • Female
  • Humans
  • Polyamines / analysis*
  • Putrescine / analysis
  • Receptors, Estrogen / analysis*
  • Spermidine / analysis
  • Spermine / analysis

Substances

  • DNA, Neoplasm
  • Polyamines
  • Receptors, Estrogen
  • Spermine
  • Spermidine
  • Putrescine