The expression of IL17RA on sputum macrophages in asthma patients

Cytokine. 2021 Jul;143:155518. doi: 10.1016/j.cyto.2021.155518. Epub 2021 Apr 8.

Abstract

IL-17A and IL-25 (IL-17 cytokines family) play an important role in the development of asthma, and allergy. Both cytokines act by binding to heterodimeric receptors with IL17RA as a common subunit. This receptor is found on macrophages, and some other cell types. The aim of the study was to determine the expression of IL17RA on asthmatic and control macrophages from induced sputum (IS) with the regard to IL-17/IL-25 background and relation to clinical features of the disease. We found an elevated expression of IL17RA on sputum macrophages in asthma patients vs controls. A characteristic sputum profile of atopic asthmatic was as follows: high CD206 + IL17RA + macrophage percentage, elevated IL-25 level and low CD206 + IL17RA- macrophage percentage. Based on the above results, it seems that CD206 + sputum macrophages are the effector cells that express common subunit of the receptor for IL-17A and IL-25 in asthma. This may be related to the Th2-dependent environment in asthma and increased concentrations of IL-25 and IL-13 as well as eosinophils in the airways. To our knowledge, our study provides the first data on a possible link between immunological reaction orchestrating CD206 + expressing sputum macrophages and IL-25 via IL17RA pathway in the asthmatic airways.

Keywords: Asthma; IL-17A; IL-25; IL17RA; Induced sputum; Macrophages.

MeSH terms

  • Adult
  • Asthma / metabolism*
  • Asthma / pathology*
  • Case-Control Studies
  • Female
  • Humans
  • Macrophages / metabolism*
  • Male
  • Mannose Receptor / metabolism
  • Middle Aged
  • Receptors, Interleukin-17 / metabolism*
  • Sputum / cytology
  • Sputum / metabolism*

Substances

  • IL17RA protein, human
  • Mannose Receptor
  • Receptors, Interleukin-17