Abstract
Phenotypic switching is the main cause of the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). We previously showed that Daxx exerted negative regulatory effect on AngII-induced VSMC proliferation and migration. However, the function of Daxx in VSMC phenotype switching remained unknown. Nicotinate-curcumin (NC) is an esterification derivative of niacin and curcumin that can prevent the formation of atherosclerosis. We found that NC significantly decreased AngII-induced VSMC phenotype switching. Furthermore, NC significantly inhibited AngII-induced cell proliferation and migration. Moreover, NC upregulated Daxx expression and regulated the PTEN/Akt signaling pathway. We concluded that NC inhibited AngII-induced VSMC phenotype switching by regulating the PTEN/Akt pathway, and through a mechanism that might be associated with the upregulation of Daxx expression.
Keywords:
Daxx; Nicotinate-curcumin; phenotype switching; vascular smooth muscle cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Atherosclerosis / prevention & control
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Cell Movement / drug effects
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Cell Proliferation / drug effects
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Cells, Cultured
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Co-Repressor Proteins / metabolism*
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Curcumin / analogs & derivatives*
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Curcumin / chemistry
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Curcumin / pharmacology
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Humans
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Molecular Chaperones / metabolism*
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Muscle, Smooth, Vascular / drug effects*
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Muscle, Smooth, Vascular / metabolism
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Muscle, Smooth, Vascular / pathology
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Myocytes, Smooth Muscle / drug effects*
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Myocytes, Smooth Muscle / metabolism
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Myocytes, Smooth Muscle / pathology
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Niacin / analogs & derivatives*
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Niacin / chemistry
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Niacin / pharmacology
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PTEN Phosphohydrolase / metabolism
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Phenotype*
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Proto-Oncogene Proteins c-akt / metabolism
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Signal Transduction / drug effects
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Up-Regulation
Substances
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Co-Repressor Proteins
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DAXX protein, human
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Molecular Chaperones
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curcumin nicotinate
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Niacin
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Proto-Oncogene Proteins c-akt
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PTEN Phosphohydrolase
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Curcumin
Grants and funding
The work was supported by National Natural Science Foundation of China [81673722, 81600291, 81670268], The National Natural Science Foundation of Hunan [2019JJ50426] The Education Department of Hunan Province [20A379, 19B401].