Esophageal disease among childhood cancer survivors-A report from the Childhood Cancer Survivors Study

Pediatr Blood Cancer. 2021 Aug;68(8):e29043. doi: 10.1002/pbc.29043. Epub 2021 Apr 12.


There is limited information addressing the occurrence of esophageal strictures among the growing population of survivors of childhood cancer. Using the Childhood Cancer Survivor Study, we analyzed data from 17,121 5-year survivors and 3400 siblings to determine the prevalence and risk factors for esophageal strictures. Prevalence among survivors was 2.0% (95% confidence interval [CI]: 1.8-2.2%), representing a 7.6-fold increased risk compared to siblings. Factors significantly associated with risk of esophageal stricture included diagnosis of Hodgkin lymphoma, greater chest radiation dose, younger age at cancer diagnosis, platinum chemotherapy, and hematopoietic stem cell transplantation. While uncommon, survivors are at risk for therapy-related esophageal strictures.

Keywords: chemotherapy; childhood cancer survivorship; esophageal disease; esophageal stricture; radiation.

MeSH terms

  • Cancer Survivors*
  • Child
  • Constriction, Pathologic
  • Esophageal Diseases / epidemiology*
  • Hodgkin Disease* / epidemiology
  • Hodgkin Disease* / therapy
  • Humans
  • Neoplasms* / epidemiology
  • Neoplasms* / therapy
  • Risk Factors
  • Survivors