Epithelioid Hemangioendothelioma in the Area of the Neurovascular Bundle of the Upper Arm Mimicking a Schwannoma of the Ulnar Nerve

J Neurol Surg A Cent Eur Neurosurg. 2022 May;83(3):294-297. doi: 10.1055/s-0041-1722969. Epub 2021 Apr 12.


Epithelioid hemangioendothelioma (EH) is a rare vascular malignant sarcoma. To date, there are only two published case reports of EH mimicking nerve sheath tumors of a peripheral nerve. A 41-year-old woman presented with a painful node on the inside of the upper arm and motor deficits of the ulnar nerve. Magnetic resonance imaging (MRI) follow-up and neurosonography revealed a slowly progressive, contrast-enhancing tumor in the area of the neurovascular bundle. A schwannoma of the ulnar nerve was suspected. At surgery, the tumor was adherent to the brachial artery, but not to nerves. Pathology revealed an EH. EH may mimic a nerve sheath tumor and should be taken into consideration, especially because of its potential for metastasis and fatal progression.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arm / pathology
  • Child
  • Female
  • Hemangioendothelioma, Epithelioid* / diagnostic imaging
  • Hemangioendothelioma, Epithelioid* / surgery
  • Humans
  • Nerve Sheath Neoplasms*
  • Neurilemmoma* / diagnostic imaging
  • Neurilemmoma* / pathology
  • Neurilemmoma* / surgery
  • Sarcoma*
  • Ulnar Nerve / diagnostic imaging
  • Ulnar Nerve / pathology