Imaging, clinical, and pathologic findings of Sertoli-leydig cell tumors

Sci Prog. 2021 Apr-Jun;104(2):368504211009668. doi: 10.1177/00368504211009668.


To explore the clinical features, imaging findings, and pathological manifestations of ovarian Sertoli-Leydig cell tumors (SLCTs). The clinical and pathological manifestations, tumor location, size, morphology, vascularity, computed tomography (CT) density, magnetic resonance imaging (MRI) signal intensity, and contrast enhancement patterns in five cases with SLCTs were retrospectively reviewed. SLCTs most commonly occurred in young women. Virilization was observed in three cases (60%). All five tumors were unilateral and oval or round, with a clear boundary. The solid part of the tumor was isoattenuated on the conventional CT scan, and showed isoattenuation or slight hypoattenuation relative to adjacent myometrium on T1 weighted imaging (T1WI) and T2 weighted imaging (T2WI). On contrast-enhanced images, three tumors showed marked enhancement. DICER1 hotspot mutations were commonly seen in SLCTs. A highly vascularized mass with low signal intensity (SI) of the solid part on T2WI and androgen overproduction symptoms may suggest an SLCT.

Keywords: CT; MRI; Sertoli-leydig cell tumors; ovary; pathology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DEAD-box RNA Helicases / genetics
  • Female
  • Humans
  • Mutation
  • Ovarian Neoplasms* / diagnostic imaging
  • Ovarian Neoplasms* / genetics
  • Retrospective Studies
  • Ribonuclease III / genetics
  • Sertoli-Leydig Cell Tumor* / diagnostic imaging
  • Sertoli-Leydig Cell Tumor* / genetics
  • Virilism


  • DICER1 protein, human
  • Ribonuclease III
  • DEAD-box RNA Helicases