Laryngeal Chondrosarcoma Characteristics and Survival Analysis in the National Cancer Database

Otolaryngol Head Neck Surg. 2022 Jan;166(1):101-108. doi: 10.1177/01945998211004578. Epub 2021 Apr 13.


Objective: To highlight various patient, tumor, diagnostic, and treatment characteristics of laryngeal chondrosarcoma (LC) as well as elucidate factors that may independently affect overall survival (OS) for LCs.

Study design: Retrospective cohort study.

Setting: National Cancer Database (NCDB).

Methods: All LC cases from 2004 to 2016 were extracted from the NCDB. Several demographic, diagnostic, and treatment variables were compared between LC subgroups using χ2 and analysis of variance tests. Univariate and multivariate survival analyses were performed for LCs using univariate Kaplan-Meier analysis and Cox proportional hazards regression models.

Results: There were 348 LCs included in the main cohort. LCs were predominantly non-Hispanic white males with similar rates of private and government insurance (49.4% vs 45.4%). Most LCs (81.6%) underwent primary surgery, particularly partial and total laryngectomy. The 1-, 5-, and 10-year survivals for LC were 95.7%, 88.2%, and 66.3%, respectively. On multivariate analysis, lack of insurance (P = .019; hazard ratio [HR], 8.21; 95% CI, 1.40-48.03), high grade (P = .001; HR, 13.51; 95% CI, 3.08-59.26), and myxoid/dedifferentiated histological subtypes (P = .0111; HR, 10.74; 95% CI, 1.71-67.33) correlated with worse OS. No difference in OS was found between partial and total laryngectomy.

Conclusion: This is the first multivariate survival analysis and largest single cohort study of LCs in the literature. Overall, LCs enjoy an excellent prognosis, with insurance status, grade, and histology as the main predictors of survival.

Keywords: National Cancer Database; chondrosarcoma of the larynx; demographic; laryngeal chondrosarcoma; malignancy; survival analysis.

MeSH terms

  • Aged
  • Chondrosarcoma / mortality*
  • Chondrosarcoma / pathology
  • Chondrosarcoma / therapy
  • Combined Modality Therapy
  • Databases, Factual
  • Female
  • Humans
  • Laryngeal Neoplasms / mortality*
  • Laryngeal Neoplasms / pathology
  • Laryngeal Neoplasms / therapy
  • Laryngectomy
  • Male
  • Margins of Excision
  • Middle Aged
  • Neoplasm Grading
  • Neoplasm Staging
  • Retrospective Studies
  • Socioeconomic Factors
  • Survival Analysis
  • Survival Rate
  • United States