A large-scale snapshot of intratumor heterogeneity in human cancer

Cancer Cell. 2021 Apr 12;39(4):463-465. doi: 10.1016/j.ccell.2021.03.005.


Using sophisticated statistical analyses on population-scale cancer whole-genome sequences, a new study published in Cell characterizes the genomic architecture of intratumor heterogeneity (ITH). It results in an unprecedented snapshot of subclones in about 30 cancer types, generating a wealth of insight into the underlying mutational events, processes, and their selection.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Genetic Heterogeneity*
  • Genomics
  • Humans
  • Mutation
  • Neoplasms* / genetics