Cancer biology: Messages in extracellular vesicles depend on centrosome number

Curr Biol. 2021 Apr 12;31(7):R337-R340. doi: 10.1016/j.cub.2021.01.057.


Extra centrosomes are linked to cancer-associated errors in cell division, metastasis and signaling. A new study reveals that centrosome amplification disrupts lysosome function, leading to the release of small extracellular vesicles and to invasive activity in pancreatic cells.