Clinical analysis of seven pediatric patients with coronavirus disease 2019 (COVID-19) in Jingzhou, Hubei, China: a retrospective study

Lanqiong Zhou; Xu Song; Hongzhu Lu; Yajun Mao; Chengbo Liu; Yan Yuan; Qihong Fan

doi:10.21037/tp-21-48

Clinical analysis of seven pediatric patients with coronavirus disease 2019 (COVID-19) in Jingzhou, Hubei, China: a retrospective study

Transl Pediatr. 2021 Mar;10(3):616-624. doi: 10.21037/tp-21-48.

Authors

Lanqiong Zhou¹, Xu Song¹, Hongzhu Lu¹, Yajun Mao¹, Chengbo Liu², Yan Yuan³, Qihong Fan¹

Affiliations

¹ Department of Pediatrics, The First Affiliated Hospital of Yangtze University, Jingzhou, China.
² Department of Clinical Laboratory, Jiang Ling Country People's Hospital, Jingzhou, China.
³ Department of Vascular Surgery, Renmin Hospital of Wuhan University, Wuhan, China.

Abstract

Background: The novel coronavirus disease 2019 (COVID-19) epidemic has spread globally, along with its incidence among children. The purpose of this study was to evaluate the clinical characteristics and outcomes of children infected with COVID-19 and to provide a reference for clinical work.

Methods: The study retrospectively reviewed the clinical characteristics and prognosis of 7 children diagnosed with COVID-19 infection at The First People's Hospital of Jingzhou between January 30 and February 29, 2020.

Results: Of the 7 cases, 2 were male and 5 were female, aged 3 months and 14 days to 12 years old (median age 3 years old). There was 1 asymptomatic carrier, 5 cases with mild type infection, which had the main symptoms of cough (4/5) and fever (4/5), and 1 case of moderate type. Among the 7 cases, serum white blood cell count was increased in 1 case, decreased in 1 case, liver transaminase was increased in 1 case, lactate dehydrogenase was increased in 3 cases, creatine kinase MB (CK-MB) was increased in 2 cases, and C-reactive protein was elevated in 2 cases. A total of 4 cases were complicated with mycoplasma pneumoniae and/or influenza B virus infection. A single case of chest computed tomography (CT) showed viral pneumonia. With routine antiviral and symptomatic support therapy, the median time taken for the results of nucleic acid testing by pharyngeal swab to become negative was 14 days (6-26 days) and the median hospital stay was 15 days (8-31 days). All participants were cured and subsequently discharged from hospital. Only 1 case was positive for nucleic acid testing by pharyngeal swab 1 month after being discharged, and the anal swab of 1 case for nucleic acid testing was positive 2 months after being discharged.

Conclusions: All children with COVID-19 who were included in this study in Jingzhou were infected via family clustering, and the laboratory examinations were not specific. Fever and cough were common symptoms, but all cases were mild and had good prognoses.

Keywords: Coronavirus disease 2019 (COVID-19); children; clinical features; outcome.