Astrocytes have a license to kill inflammatory T cells

Alice H K Kwon; Shane A Liddelow

doi:10.1016/j.immuni.2021.03.015

Astrocytes have a license to kill inflammatory T cells

Immunity. 2021 Apr 13;54(4):614-616. doi: 10.1016/j.immuni.2021.03.015.

Authors

Alice H K Kwon¹, Shane A Liddelow²

Affiliations

¹ Molecular Pathogenesis Program, the Kimmel Center for Biology and Medicine of the Skirball Institute, New York University School of Medicine, New York, NY 10016, USA. Electronic address: alice.kwon@nyulangone.org.
² Department of Neuroscience and Physiology, NYU Grossman School of Medicine, New York, NY 10016, USA; Department of Ophthalmology, NYU Grossman School of Medicine, New York, NY 10016, USA; Neuroscience Institute, NYU Grossman School of Medicine, New York, NY 10016, USA. Electronic address: shane.liddelow@nyulangone.org.

PMID: 33852828
DOI: 10.1016/j.immuni.2021.03.015

Abstract

Microbiome-induced interferon signaling through gut-derived natural killer cells is integral to minimize peripheral inflammatory responses in the brain and spinal cord. In a recent issue of Nature, Sanmarco, Wheeler, et al. define how interferon signaling induces LAMP1⁺TRAIL⁺ astrocytes, which cause death of inflammatory T cells, mitigating degeneration in a mouse model of demyealination.

MeSH terms

Animals
Astrocytes / immunology*
Brain / immunology
Disease Models, Animal
Inflammation / immunology*
Interferons / immunology
Killer Cells, Natural / immunology
Mice
Signal Transduction / immunology
Spinal Cord / immunology
T-Lymphocytes / immunology*

Substances

Interferons