Comparison of High CPAP versus NIPPV in Preterm Neonates: A Retrospective Cohort Study

Am J Perinatol. 2022 Dec;39(16):1828-1834. doi: 10.1055/s-0041-1727159. Epub 2021 Apr 14.


Objective: The aim of this study was to compare outcomes following receipt of high continuous positive airway pressure (CPAP) versus nasal intermittent positive pressure ventilation (NIPPV) in extremely preterm neonates.

Study design: We retrospectively compared outcomes of preterm neonates (22-28 weeks' gestation) following their first episode of either high CPAP (≥ 9 cm H2O) or NIPPV. Primary outcome was failure of high CPAP or NIPPV within 7 days, as determined by either need for intubation or use of an alternate noninvasive mode.

Results: During the 3-year study period, 53 infants received high CPAP, while 119 patients received NIPPV. There were no differences in the primary outcome (adjusted odds ratio 1.21; 95% confidence interval 0.49-3.01). The use of alternate mode of noninvasive support was higher with the use of high CPAP but no other outcome differences were noted.

Conclusion: Based on this cohort, there was no difference in incidence of failure between high CPAP and NIPPV, although infants receiving high CPAP were more likely to require an alternate mode of noninvasive support.

Key points: · Use of high CPAP pressures (defined as ≥9 cm H2O) is gradually increasing during care of preterm neonates.. · Limited data exists regarding its efficacy and safety.. · This study compares high CPAP with NIPPV, and demonstrates comparable short-term clinical outcomes..

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Continuous Positive Airway Pressure*
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Intermittent Positive-Pressure Ventilation*
  • Retrospective Studies

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