Loss of Transforming Growth Factor Beta Signaling in Aortic Smooth Muscle Cells Causes Endothelial Dysfunction and Aortic Hypercontractility

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1956-1971. doi: 10.1161/ATVBAHA.121.315878. Epub 2021 Apr 15.

Abstract

[Figure: see text].

Keywords: aorta; endothelium; mice; myography; transforming growth factor beta.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Aorta / metabolism
  • Aorta / pathology
  • Aorta / physiopathology
  • Aortic Aneurysm / genetics
  • Aortic Aneurysm / metabolism*
  • Aortic Aneurysm / pathology
  • Aortic Aneurysm / physiopathology
  • Cell Adhesion Molecules / metabolism
  • Dilatation, Pathologic
  • Endothelium, Vascular / metabolism*
  • Endothelium, Vascular / pathology
  • Endothelium, Vascular / physiopathology
  • Female
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Microfilament Proteins / metabolism
  • Muscle, Smooth, Vascular / metabolism*
  • Muscle, Smooth, Vascular / pathology
  • Muscle, Smooth, Vascular / physiopathology
  • Myosin Heavy Chains / genetics
  • Myosin Heavy Chains / metabolism
  • Nitric Oxide / metabolism
  • Nitric Oxide Synthase Type III / metabolism
  • Phosphoproteins / metabolism
  • Phosphorylation
  • Receptor, Transforming Growth Factor-beta Type II / deficiency*
  • Receptor, Transforming Growth Factor-beta Type II / genetics
  • Signal Transduction
  • Transforming Growth Factor beta / metabolism*
  • Vasoconstriction*

Substances

  • Cell Adhesion Molecules
  • Microfilament Proteins
  • Phosphoproteins
  • Transforming Growth Factor beta
  • myosin 11, mouse
  • vasodilator-stimulated phosphoprotein
  • Nitric Oxide
  • Nitric Oxide Synthase Type III
  • Nos3 protein, mouse
  • Receptor, Transforming Growth Factor-beta Type II
  • Tgfbr2 protein, mouse
  • Myosin Heavy Chains