Synaptotagmin-Like Protein 2a Regulates Angiogenic Lumen Formation via Weibel-Palade Body Apical Secretion of Angiopoietin-2

Arterioscler Thromb Vasc Biol. 2021 Jun;41(6):1972-1986. doi: 10.1161/ATVBAHA.121.316113. Epub 2021 Apr 15.

Abstract

[Figure: see text].

Keywords: angiopoietin-2; cell membrane; endothelial cells; secretory pathway; synaptotagmins.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Angiopoietin-2 / genetics
  • Angiopoietin-2 / metabolism*
  • Animals
  • Animals, Genetically Modified
  • Cells, Cultured
  • Exocytosis*
  • Human Umbilical Vein Endothelial Cells / metabolism*
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • Neovascularization, Physiologic*
  • Receptor, TIE-2 / metabolism
  • Signal Transduction
  • Weibel-Palade Bodies / genetics
  • Weibel-Palade Bodies / metabolism*
  • Zebrafish / genetics
  • Zebrafish Proteins / genetics
  • Zebrafish Proteins / metabolism*
  • rab27 GTP-Binding Proteins / metabolism

Substances

  • ANGPT2 protein, human
  • Angiopoietin-2
  • Membrane Proteins
  • SYTL2 protein, human
  • Zebrafish Proteins
  • rab27 GTP-Binding Proteins
  • sytl2a protein, zebrafish
  • Receptor, TIE-2
  • TEK protein, human
  • tek protein, zebrafish
  • RAB27A protein, human