Optimized hydrophobically modified chitosan cryogels for strength and drug delivery systems

Courtney Evans; Yuto Morimitsu; Tsubasa Hisadome; Futo Inomoto; Masahiro Yoshida; Takayuki Takei

doi:10.1016/j.jbiosc.2021.03.008

Optimized hydrophobically modified chitosan cryogels for strength and drug delivery systems

J Biosci Bioeng. 2021 Jul;132(1):81-87. doi: 10.1016/j.jbiosc.2021.03.008. Epub 2021 Apr 11.

Authors

Courtney Evans¹, Yuto Morimitsu², Tsubasa Hisadome³, Futo Inomoto⁴, Masahiro Yoshida⁵, Takayuki Takei⁶

Affiliations

¹ Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan. Electronic address: k6041343@kadai.jp.
² Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan. Electronic address: k2645397@kadai.jp.
³ Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan. Electronic address: k4661472@kadai.jp.
⁴ Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan. Electronic address: k0506765@kadai.jp.
⁵ Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan. Electronic address: myoshida@cen.kagoshima-u.ac.jp.
⁶ Department of Chemical Engineering, Graduate School of Science and Engineering, Kagoshima University, 1-21-40 Korimoto, Kagoshima 890-0065, Japan. Electronic address: takei@cen.kagoshima-u.ac.jp.

PMID: 33853755
DOI: 10.1016/j.jbiosc.2021.03.008

Abstract

This research reports the success of the fabrication of hydrophobically modified chitosan cryogel. Chitosan was modified with alkyl groups through reductive animation. By varying the alkyl chain length and the substitution degree, the resulting cryogel could be optimized for strength, and the adsorption and release of hydrophobic dye, a model for hydrophobic medicines. By optimizing these attributes, the hydrogel was found to have the potential as a biomedical material.

Keywords: Biomedical material; Chitosan; Cryogel; Drug carrier; Hydrophobic modification.

MeSH terms

Adsorption
Alkylation
Biocompatible Materials / chemistry*
Chitosan / chemistry*
Cryogels / chemistry*
Drug Carriers / chemistry*
Hydrophobic and Hydrophilic Interactions*
Mechanical Phenomena

Substances

Biocompatible Materials
Cryogels
Drug Carriers
Chitosan