Case control study on nutritional risk factors in celiac disease

J Pediatr Gastroenterol Nutr. 1988 May-Jun;7(3):395-9. doi: 10.1097/00005176-198805000-00013.


This study explored whether risk or protective nutritional factors have a role in childhood celiac disease. The effect of bottle feeding and early introduction of gluten to the diet was evaluated in a case control study. For each case, about 10 controls were recruited: sample size was determined as required for the evaluation of the study hypothesis. Patients were significantly less breast fed than were controls. Bottle-fed children had an earlier introduction of gluten to the diet than did controls, but when early gluten introduction was analyzed across strata of breast-fed or bottle-fed children, no risk was attributed to it. Bottle feeding appeared to be a significant risk factor in children who received gluten early as well as in those who received gluten later. Breast-feeding rates for patients and controls were equal at birth, but lower for patients by the age of 1 month: from then onward, there was a constant difference between patients and controls regarding the percentage still at breast. Interruption of breast feeding was a risk factor in celiac disease, but early gluten introduction did not appear to be a similar risk factor in the present study.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bottle Feeding / adverse effects
  • Breast Feeding
  • Celiac Disease / etiology*
  • Child, Preschool
  • Glutens / administration & dosage
  • Glutens / adverse effects
  • Humans
  • Infant
  • Infant Nutritional Physiological Phenomena*
  • Retrospective Studies
  • Risk Factors
  • Social Class
  • Time Factors


  • Glutens