Imaging recollection, familiarity, and novelty in the frontoparietal control and default mode networks and the anterior-posterior medial temporal lobe: An integrated view and meta-analysis

Neurosci Biobehav Rev. 2021 Jul:126:491-508. doi: 10.1016/j.neubiorev.2021.04.007. Epub 2021 Apr 12.

Abstract

A network-level model of recollection-based recognition (R), familiarity-based recognition (F), and novelty recognition (N) was constructed, and its validity was evaluated through meta-analyses to produce an integrated view of neuroimaging data. The model predicted the following: (a) the overall magnitude of the frontoparietal control network (FPCN) activity (which supports retrieval and decision effort) is in the order of F > R > N; (b) that of the posterior medial temporal network (MTL) activity (which plays a direct role in retrieval) is in the order of R > N > F; (c) that of the anterior MTL activity (which supports novelty-encoding) is in the order of N > R > F; (d) that of the default mode network (DMN) activity (which supports the subjective experience of remembering) is in the order of R > N > F. The meta-analyses results were consistent with these predictions. Subsystem analysis indicated a functional dissociation between the cingulo-opercular vs. frontoparietal components of the FPCN and between the core vs. medial temporal components of the DMN.

Keywords: Default mode network; Episodic memory retrieval; Familiarity; Frontoparietal control network; Medial temporal lobe; Meta-analysis; Novelty; Recollection; fMRI.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain Mapping*
  • Default Mode Network*
  • Humans
  • Magnetic Resonance Imaging
  • Mental Recall
  • Temporal Lobe