Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking

Maria F Czyzyk-Krzeska; Jarek Meller; Julio A Landero Figueroa; David R Plas; John T Cunningham

doi:10.1080/23723556.2020.1859917

Metabolic subtypes of clear cell renal cell carcinoma defined by tobacco smoking

Mol Cell Oncol. 2021 Feb 1;8(2):1859917. doi: 10.1080/23723556.2020.1859917. eCollection 2021.

Authors

Maria F Czyzyk-Krzeska^{1

2}, Jarek Meller^{3

4

5}, Julio A Landero Figueroa⁶, David R Plas¹, John T Cunningham¹

Affiliations

¹ Department of Cancer Biology, University of Cincinnati, Cincinnati, OH, USA.
² Department of Veterans Affairs, Cincinnati Veteran Affairs Medical Center, Cincinnati, OH, USA.
³ Department of Biomedical Informatics, University of Cincinnati, Cincinnati, OH, USA.
⁴ Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
⁵ Division of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati, Cincinnati, OH, USA.
⁶ Agilent Metallomics Center of the Americas, Department of Chemistry, University of Cincinnati, Cincinnati, OH, USA.

Abstract

Tobacco smoking (TS) results in reprogramming of major metabolic pathways, including glycolysis, the citric acid (TCA) cycle, oxidative phosphorylation, and metabolism of aspartate, glutamate and glutamine in clear cell renal cell carcinoma (ccRCC). TS alters the distribution and activities of cadmium, arsenic and copper in a manner mechanistically supporting metabolic remodeling. Alterations in metabolism and metal distribution identify new actionable targets for treatment of ccRCC.

Keywords: Clear cell renal cell carcinoma; arsenic; copper; oxidative phosphorylation; tobacco smoking.

Abstract

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