An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint

Eleni Petsalaki; George Zachos

doi:10.1080/23723556.2021.1877999

An ATM-CHK2-INCENP pathway prevents chromatin breakage by regulating the abscission checkpoint

Mol Cell Oncol. 2021 Feb 8;8(2):1877999. doi: 10.1080/23723556.2021.1877999. eCollection 2021.

Authors

Eleni Petsalaki¹, George Zachos¹

Affiliation

¹ Department of Biology, University of Crete, Heraklion, Greece.

Abstract

In response to chromatin bridges, the chromosomal passenger complex (CPC) delays completion of cytokinesis (abscission) to prevent chromosome breakage. Here, we discuss recent findings from our lab showing that an ATM-CHK2-INCENP pathway imposes the abscission checkpoint in human cells by regulating CPC midbody-localization.

Keywords: ATM; CHK2; CPC; Chromatin bridges; INCENP; MRN; abscission checkpoint; cytokinesis; midbody.

Grants and funding

Work in our lab was supported by Fondation Santé. Eleni Petsalaki was supported by the State Scholarships Foundation [project “Reinforcement of Postdoctoral Researchers - 2nd Cycle” grant MIS-5033021], cofinanced by Greece and the European Union.