MaTAR25: a long non-coding RNA involved in breast cancer progression

Kung-Chi Chang; David L Spector

doi:10.1080/23723556.2021.1882286

MaTAR25: a long non-coding RNA involved in breast cancer progression

Mol Cell Oncol. 2021 Feb 22;8(2):1882286. doi: 10.1080/23723556.2021.1882286. eCollection 2021.

Authors

Kung-Chi Chang^{1

2}, David L Spector^{1

2}

Affiliations

¹ Cold Spring Harbor Laboratory, New York, USA.
² Molecular and Cellular Biology Program, Stony Brook University, New York, USA.

Abstract

We recently reported on the role of Mammary Tumor Associated RNA 25 (MaTAR25) in mammary tumor cell proliferation, migration, and invasion. MaTAR25 interacts with transcriptional activator protein Pur-beta (Purb) to regulate its downstream targets such as Tensin1 in trans. The human ortholog of MaTAR25, LINC01271, is upregulated with human breast cancer stage and metastasis.

Keywords: breast cancer; lncRNA; non-coding RNA; tensin 1.

Abstract

Grants and funding