At least two to tango: Choreographing chromatin through cooperative footprints

Mol Cell. 2021 Apr 15;81(8):1591-1593. doi: 10.1016/j.molcel.2021.03.022.


Two recent papers, Rao et al. (2021), in this issue, and Sönmezer et al. (2021), investigate transcription factor cooperativity at cis-regulatory elements. Using data from nuclease- and methyltransferase-footprinting experiments, they demonstrate that factor co-occupancy at regulatory elements commonly occurs in vivo and is conserved from fly to mouse.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Chromatin* / genetics
  • Gene Expression Regulation
  • Mice
  • Protein Binding
  • Regulatory Sequences, Nucleic Acid
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism


  • Chromatin
  • Transcription Factors