The awesome power of histone genetics

Markus Nevil; Robert J Duronio

doi:10.1016/j.molcel.2021.03.023

The awesome power of histone genetics

Mol Cell. 2021 Apr 15;81(8):1593-1595. doi: 10.1016/j.molcel.2021.03.023.

Authors

Markus Nevil¹, Robert J Duronio²

Affiliations

¹ Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; SPIRE, University of North Carolina, Chapel Hill, NC 27599, USA.
² Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA; Integrative Program for Biological and Genome Sciences, University of North Carolina, Chapel Hill, NC 27599, USA; Departments of Biology and Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. Electronic address: duronio@med.unc.edu.

Abstract

Using a genetic platform to generate histone mutants in Drosophila, Regadas et al. (2021) discover a novel mechanism for tissue-specific gene expression requiring a chromatin state defined by acetylation of lysine 14 of H3 but lacking other activating histone post-translational modifications.

Publication types

Comment

MeSH terms

Acetylation
Animals
Chromatin / genetics
Gene Expression Regulation
Histones* / genetics
Histones* / metabolism
Lysine* / metabolism
Protein Processing, Post-Translational

Substances

Chromatin
Histones
Lysine

Abstract

Publication types

MeSH terms

Substances

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