NLRP3 as a sensor of metabolism gone awry

Curr Opin Biotechnol. 2021 Apr:68:300-309. doi: 10.1016/j.copbio.2021.03.009. Epub 2021 Apr 13.


The NLRP3 inflammasome is an important player in innate immunity and pathogenic inflammation. Numerous studies have implicated it in sensing endogenous danger signals, yet the precise mechanisms remain unknown. Here, we review the current knowledge on the organismal and cellular metabolic triggers engaging NLRP3, and the mechanisms involved in integrating the diverse signals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Immunity, Innate
  • Inflammasomes*
  • Inflammation
  • NLR Family, Pyrin Domain-Containing 3 Protein* / genetics


  • Inflammasomes
  • NLR Family, Pyrin Domain-Containing 3 Protein