Update on B-cell lymphoproliferative disorders of the gastrointestinal tract

Semin Diagn Pathol. 2021 Jul;38(4):14-20. doi: 10.1053/j.semdp.2021.03.006. Epub 2021 Mar 26.


The gastrointestinal (GI) tract is home to a significant portion of the immune system, which interacts daily with the antigenic milieu of its contents. Therefore, the presence of white blood cells within the walls of the GI tract upon histologic examination is a familiar sight on GI biopsies-both in health and disease. The GI tract is the most common site of extranodal lymphomas, most of which are B-cell neoplasms. Here, we review common and uncommon B-cell neoplasms of the GI tract - extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma), mantle cell lymphoma, duodenal-type follicular lymphoma, diffuse large B-cell lymphoma, plasmablastic lymphoma, EBV-positive mucocutaneous ulcer, and post-transplant lymphoproliferative disorders - with special focus on literature published during the past five years. Along with the other articles in this edition of Seminars in Diagnostic Pathology, it is the authors' hope that this review proves to be a useful resource in the workup of the array of hematopoietic processes that can involve the GI tract.

Keywords: B cell; Diffuse large B-cell lymphoma; Follicular lymphoma; Gastrointestinal tract; Lymphoma; Lymphoproliferative disorders; MALT lymphoma; Mantle cell lymphoma; Plasma cell; Post-transplant lymphoproliferative disorder.

Publication types

  • Review

MeSH terms

  • Adult
  • B-Lymphocytes
  • Gastrointestinal Neoplasms*
  • Humans
  • Lymphoma, B-Cell, Marginal Zone*
  • Lymphoproliferative Disorders*
  • Stomach Neoplasms*