Renal imaging studies at 1.5 and 9.4 T: effects of diuretics

Magn Reson Med. 1988 May;7(1):117-24. doi: 10.1002/mrm.1910070114.

Abstract

We have studied the effects of two diuretics, selective for renal cortical (furosemide) and inner medullary (vasopressin antagonist) water handling, in rat kidney at 1.5 T and find that furosemide completely dissipates the cortical-inner medullary T2 gradient whereas the vasopressin antagonist has little effect. This phenomenon appears to be related to changes in luminal water content. We also demonstrate the feasibility of obtaining live mouse kidney images with a resolution of 100 x 100 x 700 micrometers at 9.4 T.

MeSH terms

  • Animals
  • Arginine Vasopressin / analogs & derivatives
  • Arginine Vasopressin / pharmacology
  • Diuretics / pharmacology*
  • Furosemide / pharmacology
  • Kidney / anatomy & histology*
  • Kidney / drug effects
  • Kidney Cortex / anatomy & histology
  • Kidney Cortex / drug effects
  • Kidney Medulla / anatomy & histology
  • Kidney Medulla / drug effects
  • Magnetic Resonance Imaging*
  • Male
  • Mice
  • Mice, Nude
  • Rats
  • Rats, Inbred Strains

Substances

  • Diuretics
  • Arginine Vasopressin
  • Furosemide
  • 1-((beta-mercapto-beta)beta cyclopentamethylenepropionic acid)-2-(O-ethyl-Tyr)-4-Val-9-des-Gly-arginine vasopressin