Drug Discovery Inspired from Nuclear Receptor Sensing of Microbial Signals

Trends Mol Med. 2021 Jul;27(7):624-626. doi: 10.1016/j.molmed.2021.03.007. Epub 2021 Apr 14.

Abstract

Host-microbiota interactions are vital for diverse pathophysiological events and may be targeted for innovative therapeutics. Nuclear receptors (NRs) are versatile host sensors of microbial signals that coordinate diverse environmental cues with local and remote adaptions. Harnessing NR-mediated sensory machinery could provide an alternative lynchpin for gut microbiota-oriented drug discovery strategy.

Keywords: drug discovery; host–microbe interaction; microbial metabolite; nuclear receptors; target identification.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / drug effects*
  • Drug Discovery*
  • Gastrointestinal Microbiome*
  • Host Microbial Interactions*
  • Humans
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Small Molecule Libraries / pharmacology*

Substances

  • Receptors, Cytoplasmic and Nuclear
  • Small Molecule Libraries