Association of sugary drink consumption with all-cause and cause-specific mortality: the Japan Public Health Center-based Prospective Study

Hsi-Lan Huang; Sarah Krull Abe; Norie Sawada; Ribeka Takachi; Junko Ishihara; Motoki Iwasaki; Taiki Yamaji; Hiroyasu Iso; Tetsuya Mizoue; Mitsuhiko Noda; Masahiro Hashizume; Manami Inoue; Shoichiro Tsugane; JPHC Study Group

doi:10.1016/j.ypmed.2021.106561

Association of sugary drink consumption with all-cause and cause-specific mortality: the Japan Public Health Center-based Prospective Study

Prev Med. 2021 Jul:148:106561. doi: 10.1016/j.ypmed.2021.106561. Epub 2021 Apr 15.

Authors

Affiliations

¹ Department of Global Health Policy, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
² Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan.
³ Department of Food Science and Nutrition, Graduate School of Humanities and Sciences, Nara Women's University, Nara, Japan.
⁴ Department of Food and Life Science, Azabu University, Kanagawa, Japan.
⁵ Public Health, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan.
⁶ Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan.
⁷ Department of Diabetes, Metabolism and Endocrinology, Ichikawa Hospital, International University of Health and Welfare, Chiba, Japan.
⁸ Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Tokyo, Japan; Department of Cancer Epidemiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. Electronic address: mnminoue@ncc.go.jp.

PMID: 33865863
DOI: 10.1016/j.ypmed.2021.106561

Abstract

Background: Few epidemiologic studies have assessed the associations of sugary drink consumption with mortality outcomes among Asian populations.

Methods: This study included 70,486 participants in the Japan Public Health Center-based Prospective Study at the age of 45-74 years in 1995-1999. A validated food frequency questionnaire was used to assess the consumption of sugary drinks. We estimated the risk of total and cause-specific mortality associated with sugary drink consumption using Cox proportional hazards regression model.

Results: Mean follow-up was 17.1 years, during which 11,811 deaths were documented. Sugary drink consumption was associated with higher total mortality, with multivariate HR of 1.06 (95% CI 1.00-1.13) for quintile 3, 1.07 (95% CI 1.01-1.13) for quintile 4, and 1.15 (95% CI 1.09-1.22) for quintile 5, compared with quintile 1 (P < 0.001 for trend). Additionally, positive associations with cause-specific mortality were observed, including death from circulatory system diseases (quintile 5 vs quintile 1; HR, 1.23; 95% CI 1.09-1.38) and heart disease (quintile 5 vs quintile 1; HR, 1.35; 95% CI 1.14-1.60).

Conclusion: In this large Japanese prospective study, sugary drink consumption was associated with all-cause and cause-specific mortality.

Keywords: JPHC study; Japan; Mortality; Prospective cohort study; Sugary drinks.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Cardiovascular Diseases*
Cause of Death
Humans
Japan / epidemiology
Middle Aged
Proportional Hazards Models
Prospective Studies