Diffuse White Adipose Tissue 18F-FDG Uptake-An Unusual Finding on 18F-FDG PET/CT

Clin Nucl Med. 2021 Oct 1;46(10):e513-e514. doi: 10.1097/RLU.0000000000003652.


Brown adipose tissue of cervical, supraclavicular, and paravertebral regions can show increased FDG uptake. But human white adipose tissue (WAT) shows negligible FDG uptake on 18F-FDG PET/CT scan. We present a case of carcinoma cervix treated with concurrent chemoradiation. 18F-FDG PET/CT shows altered biodistribution of FDG with intense FDG uptake throughout the WAT. Later on, patient confirmed taking herbal medication for herpes zoster infection, which could contain corticosteroids, resulting in enhanced WAT uptake of 18F-FDG.

Publication types

  • Case Reports

MeSH terms

  • Adipose Tissue, Brown / diagnostic imaging
  • Adipose Tissue, Brown / metabolism
  • Adipose Tissue, White
  • Female
  • Fluorodeoxyglucose F18* / metabolism
  • Humans
  • Positron Emission Tomography Computed Tomography*
  • Positron-Emission Tomography
  • Radiopharmaceuticals / metabolism
  • Tissue Distribution


  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18