Improving the Acceptability of Human Papillomavirus Vaccines Among Men Who Have Sex With Men According to the Associated Factors: A Systematic Review and Meta-analysis

Yang Zhao; Xiaoli Xin; Huiwen Deng; Junjie Xu; Wenjia Weng; Ming Zhang; Juan Li; Yanqing Gao; Xiaojie Huang; Cuie Liu

doi:10.3389/fphar.2021.600273

Improving the Acceptability of Human Papillomavirus Vaccines Among Men Who Have Sex With Men According to the Associated Factors: A Systematic Review and Meta-analysis

Front Pharmacol. 2021 Mar 24:12:600273. doi: 10.3389/fphar.2021.600273. eCollection 2021.

Authors

Yang Zhao¹, Xiaoli Xin², Huiwen Deng³, Junjie Xu⁴, Wenjia Weng¹, Ming Zhang¹, Juan Li¹, Yanqing Gao¹, Xiaojie Huang⁵, Cuie Liu^{1

6}

Affiliations

¹ Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing, China.
² Shenyang Sixth People's Hospital of Shenyang, Shenyang, China.
³ The First Hospital of China Medical University, Shenyang, China.
⁴ Key Laboratory of AIDS Immunology of Liaoning Province, the First Affiliated Hospital of China Medical University, Shenyang, China.
⁵ Center for Infectious Diseases,Beijing Youan Hospital, Capital Medical University, Beijing, China.
⁶ Candidate Branch of National Clinical Research Center for Skin Diseases, Beijing, China.

Abstract

Objectives: To investigate the acceptability of human papillomavirus (HPV) vaccination among men who have sex with men (MSM) and its associated factors. Methods: We searched studies written in English in PubMed, EMBASE, and Web of Science with no geographical or time restrictions. We evaluated the quality of the included literature. We calculated the pooled acceptability and performed meta-analysis of selected studies, including factors associated with the acceptability among MSM, using Review Manager (v5.3). Results: The acceptability among the 15 studies (n = 8,658) was 50% (95% CI: 0.27-0.72). The meta-analysis of seven articles (n = 4,200) indicated that having a college or higher degree (OR = 1.62, 95% CI: 1.35-1.95), disclosure of sexual orientation to healthcare professionals (HCPs; OR = 2.38, 95% CI: 1.47-3.86), vaccination with at least one dose for hepatitis A or B (OR = 2.10, 95% CI: 1.42-3.10), awareness of HPV (OR = 1.85, 95% CI: 1.21-2.83), knowledge of HPV (SMD = 0.28, 95% CI: 0.16-0.39), perceived susceptibility to HPV infection (SMD = 0.31, 95% CI: 0.11-0.50), and perceived severity of HPV-related disease (SMD = 0.40, 95% CI: 0.28-0.51) can promote acceptance of HPV vaccines. Meanwhile, people who have had unprotected anal sex or have more sex partners tend to have low acceptance of HPV vaccines. Conclusions: HPV education should be actively promoted according to the factors that influence the acceptability of HPV vaccines among the MSM population. HPV education should be especially aimed at people with low academic qualifications and people with risky sexual behaviors, and should emphasize the aspects of susceptibility to and severity of HPV-related disease. More intervention trials should be conducted to increase the credibility of the results.

Keywords: HPV vaccine; acceptability; human papilloma virus; men who have sex with men; systematic review.