Background: Granulomatosis with polyangiitis is a necrotizing inflammation of small and medium-sized vessels accompanied by formation of granuloma, involvement of primary granulomatous upper and lower respiratory tracts, glomerulonephritis, and vasculitis of small vessels.
Case summary: Herein, we described a case of a 52-year-old man admitted with pulmonary nodules and high fever. Autoantibody workup revealed that the patient was positive for c-anti-neutrophil cytoplasmic antibodies and proteinase-3 anti-neutrophil cytoplasmic antibodies. Pulmonary biopsies revealed a local granulomatous structure. The patient received therapy with methylprednisolone and intravenous immunoglobulin, and his clinical symptoms improved.
Conclusion: Intravenous immunoglobulin may act on granulomatosis with polyangiitis similar to immunosuppressants.
Keywords: Case report; Diffuse alveolar hemorrhage; Granulomatosis with polyangiitis; Intravenous immunoglobulin; Methylprednisolone; Otitis media.
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