Daptomycin versus teicoplanin in the treatment of osteomyelitis: Results of the Göztepe retrospective cohort study

Infect Dis Now. 2021 Jun;51(4):362-367. doi: 10.1016/j.idnow.2021.01.009. Epub 2021 Jan 22.


Objectives: Daptomycin is highly effective against Gram-positive multidrug-resistant bacteria. Publications on daptomycin in osteomyelitis treatment are limited.

Patients and methods: In this multicenter retrospective cohort study, the aim was to evaluate the outcomes of osteomyelitis cases having received daptomycin or teicoplanin. This multicenter retrospective cohort study gathered data from seven centers located in five cities of Turkey. Study inclusion criteria were as follows: (a) magnetic resonance imaging and/or direct X-ray revealed osteomyelitis or biopsy pathologic examination results concomitant with osteomyelitis. Chi-squareand Student t-tests were used for statistical comparison.

Results: A total of 72 patients, 38 cases in the daptomycin group and 34 cases in the teicoplanin group diagnosed with osteomyelitis fulfilling the study inclusion criteria, were included in the study. Clinical success at the end of induction therapy was achieved in 32/38 cases in the daptomycin cohort vs. 30/34 cases in the teicoplanin cohort (p: 0.73).

Conclusion: Although this is a limited experience in a small but well-defined cohort, our data suggest that daptomycin may be a safe alternative to glycopeptides in osteomyelitis treatment. A randomized controlled clinical study involving larger cohorts may increase the available evidence.

Keywords: Bone & joint infections; Debridement; Glycopeptides; Lipopeptides; Vancomycin.

Publication types

  • Multicenter Study

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / therapeutic use*
  • Cohort Studies
  • Daptomycin / therapeutic use*
  • Drug Resistance, Multiple, Bacterial
  • Female
  • Glycopeptides / therapeutic use
  • Humans
  • Male
  • Middle Aged
  • Osteomyelitis / drug therapy*
  • Retrospective Studies
  • Teicoplanin / therapeutic use*
  • Treatment Outcome
  • Turkey
  • Vancomycin / therapeutic use


  • Anti-Bacterial Agents
  • Glycopeptides
  • Teicoplanin
  • Vancomycin
  • Daptomycin