Adipose-derived stem cell exosomes facilitate rotator cuff repair by mediating tendon-derived stem cells

Regen Med. 2021 Apr;16(4):359-372. doi: 10.2217/rme-2021-0004. Epub 2021 Apr 19.

Abstract

Aim: To evaluate the potential capability of adipose-derived stem cell exosomes (ADSC-exos) on rotator cuff repair by mediating the tendon-derived stem cells (TDSCs) and explored the mechanism. Methods: First, we investigated the growth, survival and migration of TDSCs in the presence of ADSC-exos in vitro. Using a rat rotator cuff injury model to analyze the ability of the ADSC-exos to promote rotator cuff healing in vivo. Results: The hydrogel with ADSC-exos significantly improved the osteogenic and adipogenesis differentiation and enhanced the expression of RUNX2, Sox-9, TNMD, TNC and Scx and the mechanical properties of the articular portion. Conclusion: The ADSC-exos have the potential to promote the rotator cuff repair by mediating the TDSCs.

Keywords: exosomes; muscle regeneration; rotator cuff tear; tendon-derived stem cells.

Publication types

  • Research Support, Non-U.S. Gov't