Early Safety Monitoring of COVID-19 Vaccines in Healthcare Workers

J Korean Med Sci. 2021 Apr 19;36(15):e110. doi: 10.3346/jkms.2021.36.e110.


Hospital-based surveillance for adverse events was conducted on healthcare workers after they received the first dose of coronavirus disease 2019 (COVID-19) vaccine. Among the two new platform vaccines (messenger RNA- and adenoviral vector-based vaccines), the rates of systemic adverse events were significantly higher among adenovirus-vectored vaccine recipients. Fatigue (87.6% vs. 53.8%), myalgia (80.8% vs. 50.0%), headache (72.0% vs. 28.8%), and fever (≥ 38.0°C, 38.7% vs. 0%) were the most common adverse events among adenovirus-vectored vaccine recipients, but most symptoms resolved within 2 days. Both types of COVID-19 vaccines were generally safe, and serious adverse events rarely occurred.

Keywords: Adverse Event; COVID-19; Safety; Surveillance; Vaccine.

MeSH terms

  • Adult
  • Aged
  • COVID-19 / prevention & control*
  • COVID-19 Vaccines / adverse effects*
  • Female
  • Health Personnel*
  • Humans
  • Male
  • Middle Aged
  • SARS-CoV-2 / immunology*
  • Vaccination / adverse effects*


  • COVID-19 Vaccines