Ehrlichia-induced hemophagocytic lymphohistiocytosis after autologous stem cell transplant

Transpl Infect Dis. 2021 Aug;23(4):e13621. doi: 10.1111/tid.13621. Epub 2021 Apr 30.


Hemophagocytic lymphohistiocytosis (HLH) causes multiorgan failure due to the release of multiple cytokines mediating widespread inflammation. We present a patient with multiple myeloma on maintenance chemotherapy with the anti-CD38 monoclonal antibody daratumumab after autologous stem cell transplant (ASCT) who developed fatal HLH secondary to Ehrlichiosis.

Keywords: Ehrlichia; hemophagocytic lymphohistiocytosis (HLH); multiorgan failure; multiple myeloma; stem cell transplant.

Publication types

  • Case Reports

MeSH terms

  • Ehrlichia chaffeensis*
  • Ehrlichiosis* / drug therapy
  • Humans
  • Lymphohistiocytosis, Hemophagocytic* / etiology
  • Lymphohistiocytosis, Hemophagocytic* / therapy
  • Multiple Organ Failure / etiology
  • Stem Cell Transplantation / adverse effects