Integrative approach identifies SLC6A20 and CXCR6 as putative causal genes for the COVID-19 GWAS signal in the 3p21.31 locus

medRxiv [Preprint]. 2021 Apr 13:2021.04.09.21255184. doi: 10.1101/2021.04.09.21255184.


To date the locus with the most robust human genetic association to COVID-19 susceptibility is 3p21.31. Here, we integrate genome-scale CRISPR loss-of-function screens and eQTLs in diverse cell types and tissues to pinpoint genes underlying COVID-19 risk. Our findings identify SLC6A20 and CXCR6 as putative causal genes that mediate COVID-19 risk and highlight the usefulness of this integrative approach to bridge the divide between correlational and causal studies of human biology.

Keywords: COVID-19; CRISPR; GWAS; SARS-CoV-2; eQTL.

Publication types

  • Preprint